Andesmar Cama Suite
Cama Suite 24-seat 180° flat
3-5x daily overnight
Buenos Aires to Mendoza (wine country) is Argentina's long-haul overnight bus route across the pampas. Cama Suite + Ejecutivo class from Retiro Bus Terminal 18:00-21:00 for 08:00-11:00 arrival. Andesmar + Cata Internacional are the premium operators — 180° flat beds, meals, and champagne. Flag Argentina domestic flights are often price-competitive with premium overnight buses (Aerolíneas Argentinas + Flybondi + JetSmart), so evaluate both. Bus makes sense for the "overnight sleep + save hotel" trip.
Cama Suite 24-seat 180° flat
3-5x daily overnight
Cama 160° recline
2-4x daily
Semi-Cama 40-seat
4-6x daily
Live schedules + prices. Cancel free 24h before departure.
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Overnight Cama Suite bus (14h + flat bed) is genuinely comparable to a flight when you factor in: cost (bus $35-50 vs flight $60-150), saved hotel night ($40-80 saved), and door-to-door time (bus Retiro-Mendoza terminal 14h vs flight EZE-MDZ 8h door-to-door). For overnight trips: bus can win.
Cama Suite = 180° fully flat bed (24 seats per bus). Semi-Cama = 160° recline (40 seats). Suite is genuinely comfortable overnight sleep + costs ~1.5x more. For a 14h overnight: worth the premium if you value sleep.
13-16 hours depending on operator + route. Andesmar direct is fastest (~13h). Buses stopping at Rosario/Córdoba/San Luis: 15-16h. Overnight schedule typical: dep 20:00, arr 09:00-11:00.
Mendoza Terminal (west side, 3 km from central) — take a taxi (ARS 3,000-5,000) or Cabify to central Mendoza. Terminal has hotels + wine-tour operators booking desks.